• A. Ghomri High Scool of Applied Science of Tlemcen
  • N. Missoum Laboratory of Natural and Bioactive Substances LASNABIO, Tlemcen University, Tlemcen
  • S. Bouchentouf Laboratory of Natural and Bioactive Substances LASNABIO, Tlemcen University, Tlemcen



Protein/protein interaction; Sulfur; Docking; Molecular dynamic


Diabetes pathology present actualy a real public health problem. In order to highlight the most favored modes of interaction between insulin and its receptor, and thus elucidated the substitution effect of sulfur by other element (selinum) in the receptor bridges on its affinity for the insulin, we elaborate a theoretical study by molecular modeling namely molecular docking (more commonly known as docking) between insulin and the insulin receptor with disulphide bridges and diselenide bridges. Complexes (insulin/receptor) stability was elucidated using molecular dynamics methodes. Our results show that there is a difference between the interaction energies. Indeed, the selinium substitution of sulfur implied good complementarity between isinsulin and its receptor this is in good agreement with several experimental findings.


Download data is not yet available.


[1] Schrauzer G N. Critical Reviews in Biotechnology. 2009, 29 (1), 10-17, DOI: 10.1080/07388550802658048.
[2] Navarro-Alarcón M, López-Martı́nez M C, Science of The Total Environment. 2000, 249, 347-371, DOI: 10.1016/S0048-9697(99)00526-4.
[3] Park K, Rimm EB, Siscovick DS, Spiegelman D, Manson JE, Morris JS, Hu FB, Mozaffarian D. Diabetes Care. 2012, 35(7),1544-1551, Doi: 10.2337/dc11-2136.
[4] Ostenson C G, The pathophysiology of type 2 diabetesmellitus : anoverview . actaphysiolscand , 2001, 171, 241-247.
[5] Youngren, J.F. Cell Mol Life Sci . 2007. 64, 873-91, DOI: 10.1007/s00018-007-6359-9.
[6] Jensen M, De Meyts P. Molecular mechanisms of differentialintracellular signaling from the insulin receptor. Vitam Horm. 2009, 80, 51-75.
[7] Kojima H, Fujimiya M, Terashima T, Kimura H, Chan L. Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself? Endocr J. 2006, 53, 715-22.
[8] Denis U. (2002). Etude pharmacologique de la voie de signalisation impliquée dansl’apoptose des péricytes rétiniens induite par les produits avancés de glycation (albumine bovine modifiée par le méthylglyoxal). Thèse de doctorat, L’institut National des Sciences Appliquées. Lyon I.
[9] Capeau J. Insulin signaling: mechanisms altered in insulin resistance. Med Sci (Paris). 2003, 19(8-9), 834-9.
[10] Croll TI, Smith BJ, Margetts MB, Whittaker J, Weiss MA, Ward CW, Lawrence MC. Structure. 2016, 24, 469–476.
[11] Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001, 414, 799–806.
[12] Miller KA, and al. 2010 Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae. Eukaryot Cell 9(11):1669-79.
[13] Chemical Computing Group, Scientific Vector Language,, 2018.
[14] David W. Ritchie,Hex 8.0.0 User Manual. Protein Docking Using Spherical Polar Fourier Correlations Copyright c 1996-2013.
[15] Akbaraly TN, et al., Plasma selenium and risk of dysglycemia in an elderly French population: resultsfrom the prospective Epidemiology of VascularAgeingStudy. NutrMetab (Lond), 2010. 7: p. 21.
[16] Ayad A. (2009) Evaluation of the selenium level in a sample of the diabetic population of the city of Tlemcen, Master thesis, Aboubekr Belkaid University. Tlemcen.




How to Cite

GHOMRI, A.; MISSOUM, N.; BOUCHENTOUF, S. THEORETICAL STUDY OF THE SUBSTITUTION EFFECT ON THE PROTEIN/PROTEIN INTERACTION: APPLICATION ON DIABET DESEASE. Journal of Fundamental and Applied Sciences, [S. l.], v. 12, n. 1S, p. 278–287, 2019. DOI: 10.4314/jfas.v12i1S.20. Disponível em: Acesso em: 24 mar. 2023.

Most read articles by the same author(s)