• N. Mebarki Food Technology Research Laboratory, FSI, University of Boumerdes 35000, Algeria
  • M. Nabiev Department of Chemical and Pharmaceutical Process Engineering, FHC, University of Boumerdes 35000, Algeria
  • H. Ziane Microbiology Laboratory, Centre Hospitalo-Universitaire Mustapha, Place du 1er Mai 1945, Sidi M’Hamed, Alger, 16000, Algeria
  • H. Chader National Laboratory for the Control of Pharmaceutical Products (LNCPP), Route du petit Staouéli, Dély-Brahim, Alger, 16096, Algeria
  • F. Fazouane Food Technology Research Laboratory, FSI, University of Boumerdes 35000, Algeria



Thyme; essential oil; antimicrobial activity; skin irritation; cutaneous infections.


The aim of the present study was to develop and evaluate a topical formulation containing Thymus fontanesii Boiss. & Reut essential oil that could serve as an antimicrobial agent for the treatment of various skin diseases caused by bacteria, yeast and dermatophytes. The selected formulation exhibited a significant antimicrobial activity against all tested strains, better consistency, good homogeneity, no skin irritation and good stability for six months at 25 ± 2°C. Our results demonstrate that the formulation could be used safely as topical preparation to treat skin diseases caused by the tested microorganisms into the future.


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How to Cite

MEBARKI, N.; NABIEV, M.; ZIANE, H.; CHADER, H.; FAZOUANE, F. PREPARATION, CHARACTERIZATION AND IN VITRO ANTIMICROBIAL ACTIVITY EVALUATION OF THYME ESSENTIAL OIL FORMULATION TO TREAT SKIN INFECTIONS. Journal of Fundamental and Applied Sciences, [S. l.], v. 12, n. 1S, p. 1–16, 2019. DOI: 10.4314/jfas.v12i1S.1. Disponível em: Acesso em: 24 mar. 2023.