• Ratheesh . Sadanandan Depatment of Biochemistry, University of Kerala, Trivandrum-695581, Kerala, India
  • Anoop Appu Depatment of Biochemistry, University of Kerala, Trivandrum-695581, Kerala, India
  • Arun. A. Rauf Depatment of Biochemistry, University of Kerala, Trivandrum-695581, Kerala, India



Marine algae, Gracilaria verrucosa, gel filtration chromatography, antibacterial activity, disc diffusion method.


Lectins are univalent or polyvalent carbohydrate-binding proteins of non-immune origin that are widely distributed in the marine ecosystem. A lectin was isolated from marine algae Gracilaria verrucosa by G-100 gel filtration chromatography. This lectin was named GVL, agglutinated rat, rabbit, goat, chicken and human ABO erythrocytes. The antibacterial activity of this algal lectin was studied using disc diffusion method. GVL exhibited potent antibacterial activity against bacteria such as E.coli, S.pyogenes, S. aureus, E.faecalis, B.subtilis and coagulase-negative Staphylococci (CoNS) by disc diffusion method. Also, the results were compared with the standard antibiotic Ampicillin. These findings indicate that GVL is having therapeutic applications with great importance in clinical microbiology.


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How to Cite

SADANANDAN , R. .; APPU, A. .; RAUF, A. A. . ANTIBACTERIAL ACTIVITY OF GVL, A LECTIN ISOLATED FROM MARINE ALGAE GRACILARIA VERRUCOSA. Journal of Fundamental and Applied Sciences, [S. l.], v. 14, n. 3, p. 509–517, 2022. DOI: 10.4314/jfas.1224. Disponível em: Acesso em: 4 dec. 2023.